Communication between corneal epithelial cells and trigeminal neurons is facilitated by purinergic (P2) and glutamatergic receptors.
Previously, we demonstrated that nucleotides released upon mechanical injury to corneal epithelium activate purinergic (P2) receptors resulting in mobilization of a Ca(2+) wave.However, the tissue is extensively innervated and communication between epithelium and neurons is critical and not well understood.Therefore, we developed a co-culture choru